Studies have shown an association between increased physical activity and reduced inflammation.[34] It produces both a short-term inflammatory response and a long-term anti-inflammatory effect.[35] Physical activity reduces inflammation in conjunction with or independent of changes in body weight.[36] However, the mechanisms linking physical activity to inflammation are unknown.
Developing research has demonstrated that many of the benefits of exercise are mediated through the role of skeletal muscle as an endocrine organ. That is, contracting muscles release multiple substances known as myokines, which promote the growth of new tissue, tissue repair, and various anti-inflammatory functions, which in turn reduce the risk of developing various inflammatory diseases.[13]
^ Colbert LH, Visser M, Simonsick EM, Tracy RP, Newman AB, Kritchevsky SB, Pahor M, Taaffe DR, Brach J, Rubin S, Harris TB (July 2004). "Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study". Journal of the American Geriatrics Society. 52 (7): 1098–104. doi:10.1111/j.1532-5415.2004.52307.x. PMID 15209647.

The Physical Activity Guidelines for Americans were created by the Office of Disease Prevention and Health Promotion. This publication recommends that all adults should avoid inactivity to promote good health mentally and physically. For substantial health benefits, adults should participate in at least 150 minutes a week of moderate-intensity, or 75 minutes a week of vigorous-intensity aerobic physical activity, or an equivalent combination of moderate- and vigorous-intensity aerobic activity. Aerobic activity should be performed in episodes of at least 10 minutes, and preferably, it should be spread throughout the week.
Becoming physically fit requires a change in life style as well. You will have to incorporate a regular exercise routine in your life and also eat healthier. By avoiding junk foods, fizzy drinks, bad habits like smoking and alcohol and by getting adequate amount of rest, you will be able to become physically and mentally fit. Just by eliminating all these food substances from your life, no matter how temporarily, you will allow your body to detox and become stronger. Make sure that you spend more time outdoors in the sun, and fresh air and take part in more healthy activities. Fishing, bicycling, swimming, hiking, and even playing foot ball with your kids should be a part of your physically fit lifestyle.

These recommendations are also widely supported by the American Cancer Society. The guidelines have been evaluated and individuals that have higher guideline adherence scores substantially reduce cancer risk as well as help towards control with a multitude of chronic health problems. Regular physical activity is a factor that helps reduce an individual’s blood pressure and improves cholesterol levels, two key components that correlate with heart disease and Type 2 Diabetes.[33] The American Cancer Society encourages the public to "adopt a physically active lifestyle" by meeting the criteria in a variety of physical activities such as hiking, swimming, circuit training, resistance training, lifting, etc. It is understood that cancer is not a disease that can be cured by physical fitness alone, however, because it is a multifactorial disease, physical fitness is a controllable prevention. The large associations tied with being physically fit and reduced cancer risk are enough to provide a strategy to reduce cancer risk.[32] The American Cancer Society asserts different levels of activity ranging from moderate to vigorous to clarify the recommended time spent on a physical activity. These classifications of physical activity consider the intentional exercise and basic activities are done on a daily basis and give the public a greater understanding of what fitness levels suffice as future disease prevention. 
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